Our process chemistry R&D team has extensive experiences in developing and scaling up multi-step processes for complex heterocycles, benzenes, metal-organic compounds etc. They will consider all aspects of cost, quality, and safety etc in order to develop the most appropriate process based on the stage of a project.  Our service and strength areas include but are not limited to:

• Route scouting and optimization
• Alternative reagent and catalyst screening
• Solvent screening
• Impurity analysis, identification and synthesis based on certain strategies
• NoR and PaR studies
• DoE/QbD studies
• IND/NDA stage process development and registration support
• Final process development for commercial production of APIs and intermediates
• API recrystallization process development and optimization

Our state-of-the-art laboratory is equipped with equipped with parallel synthesizers, catalyst screening autoclaves, double-jacked flask with fully-automated and controlled utilities and data acquisition software. Our dedicated team of experts explore and practice new technologies such as biocatalysis chemistry, flow chemistry and photo chemistry etc. The process development team at Bellen with more than 270 comprises highly qualified scientists and skilled chemists with 5 more years extensive experience.

The chemistry we specialize in including but not limited to asymmetric synthesis, Suzuki coupling, Sonagashira coupling, Kumada and Heck coupling, as well as Grignard reactions, classical halogenation, carbonylation, ozonation, Buchwald amination, chiral reduction, construction of heterocycles and many others.